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HomeNatureWhere did COVID-19 come from? Evidence points to raccoon dogs

Where did COVID-19 come from? Evidence points to raccoon dogs

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A raccoon dog pauses of a grassy verge in Germany.

Raccoon dogs are eaten and used for their fur in some countries.Credit: Bernhardt Reiner/Prisma by Dukas Presseagentur via Alamy

Five years on from the beginning of the COVID-19 pandemic, scientists are still trying to pin down where the virus that causes the disease came from. The number one suspect is the raccoon dog (Nyctereutes procyonoides) because they were being sold at the market where scientists believe the first cases spilled over from animals to humans, and were probably involved in passing another, related, virus to people in 2003. However, raccoon dogs have been studied as viral hosts more than other animals, including ones also present at the market, says evolutionary biologist Michael Worobey. So, there could be other, less well-studied candidates.

Nature | 7 min read

Three weeks after the Trump administration issued a directive to freeze payment on all federal grants and loans, almost all grant-review meetings remain suspended at the US National Institutes of Health (NIH). This is despite a judge putting it on hold after lawsuits challenging the order’s legality. The freeze has continued thanks to a ‘loophole’ in the process that the administration is exploiting. To run a grant-review session, the NIH must post their plans on a publication called the Federal Register, which the Trump administration has halted. Some legal scholars say this approach to withholding funds is illegal.

Nature | 7 min read

What’s AI up to?

Researchers have developed an artificial-intelligence (AI) tool that can diagnose a range of infections and health conditions in one sweep, by screening immune-cell gene sequences in blood samples. In a study of nearly 600 people, the tool identified whether participants were healthy or had COVID-19, type 1 diabetes, HIV or the autoimmune disease lupus, as well as whether they had recently received a flu vaccine. The tool could one day help clinicians to deal with “conditions that today don’t have definitive tests”, says study co-author Maxim Zaslavsky.

Nature | 5 min read

Reference: Science paper

Scientists have unveiled Evo-2, an artificial-intelligence (AI) model that can write whole chromosomes and small genomes from scratch. The model — which was trained on 128,000 genomes spanning the tree of life, from humans to single-celled bacteria and archaea — can also make sense of existing DNA, including hard-to-interpret ‘non-coding’ gene variants that are linked to disease. Researchers seem impressed by what they’ve read about Evo-2, but note that they’ll need to try it for themselves before coming to firm conclusions.

Nature | 6 min read

Reference: Paper posted to Arc Institute (not peer reviewed)

Features & opinion

Neuroscientist Robin Mazumder proposes the concept of ‘neuromimicry’ to explore how we use the design of the brain to influence urban planning. For instance, we could separate the districts of a city by activity – as specific parts of the brain have specialized functions – to pool resources, and improve the experience of transport networks by making them better connected. “Neuromimicry points to how we can intentionally design evidence-informed thriving cities in a rapidly urbanizing world to support planetary health,” Mazumder writes.

Nature Human Behaviour | 9 min read

Andrew Robinson’s pick of the top five science books to read this week includes an environmental horror story in graphic-novel form and an explanation of how humans stay alive in a world of diseases.

Nature | 4 min read

A young man watches history repeat itself in the latest short story for Nature’s Futures series.

Nature | 7 min read

Racial discrimination could be eliminated from workers’ ratings by switching from a five-star system — which allows people to impart their personal opinions — to a thumbs up or down. In a study of an online platform that connected customers to workers who performed home repair jobs, researchers found that with a five-star rating system, people they categorized as ‘non-white’ had lower ratings and got paid less than their white counterparts. When they changed the system to thumbs up or down, which focused raters on simply marking the service as good or bad, the effect disappeared.

Nature Podcast | 32 min listen

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QUOTE OF THE DAY

The estimated chance that the asteroid known as 2024 YR4 will impact the Earth in 2032 has dropped from 3.1% — the greatest such threat ever recorded — to 1.5%. It is expected to keep dropping, says Richard Moissl, head of the European Space Agency’s Planetary Defence Office, but it is only a matter of time before a more serious threat comes along. (Nature | 5 min read)

Today, Leif Penguinson is scaling a sandstone cliff face in the Waterberg Plateau National Park, Namibia. Can you find the penguin?

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