Proske, U. & Gandevia, S. C. The proprioceptive senses: their roles in signaling body shape, body position and movement, and muscle force. Physiol. Rev. 92, 1651–1697 (2012).
Tuthill, J. C. & Azim, E. Proprioception. Curr. Biol. 28, R194–R203 (2018).
Azim, E. & Seki, K. Gain control in the sensorimotor system. Curr. Opin. Physiol. 8, 177–187 (2019).
Wolf, H. & Burrows, M. Proprioceptive sensory neurons of a locust leg receive rhythmic presynaptic inhibition during walking. J. Neurosci. 15, 5623–5636 (1995).
Fink, A. J. P. et al. Presynaptic inhibition of spinal sensory feedback ensures smooth movement. Nature 509, 43–48 (2014).
Koch, S. C. et al. RORβ spinal interneurons gate sensory transmission during locomotion to secure a fluid walking gait. Neuron 96, 1419–1431 (2017).
Azevedo, A. et al. Connectomic reconstruction of a female Drosophila ventral nerve cord. Nature 631, 360–368 (2024).
Takemura, S. et al. A connectome of the male Drosophila ventral nerve cord. eLife 13, RP97769 (2024).
Marin, E. C. et al. Systematic annotation of a complete adult male Drosophila nerve cord connectome reveals principles of functional organisation. eLife 13, RP97766 (2024).
Rossignol, S., Dubuc, R. & Gossard, J.-P. Dynamic sensorimotor interactions in locomotion. Physiol. Rev. 86, 89–154 (2006).
Dallmann, C. J., Karashchuk, P., Brunton, B. W. & Tuthill, J. C. A leg to stand on: computational models of proprioception. Curr. Opin. Physiol. 22, 100426 (2021).
Frigon, A., Akay, T. & Prilutsky, B. I. Control of mammalian locomotion by somatosensory feedback Compr. Physiol. 12, 2877–2947 (2021).
McComas, A. J. Hypothesis: Hughlings Jackson and presynaptic inhibition: is there a big picture? J. Neurophysiol. 116, 41–50 (2016).
Crapse, T. B. & Sommer, M. A. Corollary discharge across the animal kingdom. Nat. Rev. Neurosci. 9, 587–600 (2008).
Straka, H., Simmers, J. & Chagnaud, B. P. A new perspective on predictive motor signaling. Curr. Biol. 28, R232–R243 (2018).
Cullen, K. E. Sensory signals during active versus passive movement. Curr. Opin. Neurobiol. 14, 698–706 (2004).
Daly, K. C. & Dacks, A. The self as part of the sensory ecology: how behavior affects sensation from the inside out. Curr. Opin. Insect Sci. 58, 101053 (2023).
Clarac, F. & Cattaert, D. Invertebrate presynaptic inhibition and motor control. Exp. Brain Res. 112, 163–180 (1996).
Rudomin, P. & Schmidt, R. F. Presynaptic inhibition in the vertebrate spinal cord revisited. Exp. Brain Res. 129, 1–37 (1999).
Kuan, A. T. et al. Dense neuronal reconstruction through X-ray holographic nano-tomography. Nat. Neurosci. 23, 1637–1643 (2020).
Mamiya, A., Gurung, P. & Tuthill, J. C. Neural coding of leg proprioception in Drosophila. Neuron 100, 636–650 (2018).
Mamiya, A. et al. Biomechanical origins of proprioceptor feature selectivity and topographic maps in the Drosophila leg. Neuron 111, 3230–3243 (2023).
Agrawal, S. et al. Central processing of leg proprioception in Drosophila. eLife 9, e60299 (2020).
Chen, C. et al. Functional architecture of neural circuits for leg proprioception in Drosophila. Curr. Biol. 31, 5163–5175 (2021).
Chockley, A. S. et al. Subsets of leg proprioceptors influence leg kinematics but not interleg coordination in Drosophila melanogaster walking. J. Exp. Biol. 225, jeb244245 (2022).
Lee, S.-Y. J., Dallmann, C. J., Cook, A., Tuthill, J. C. & Agrawal, S. Divergent neural circuits for proprioceptive and exteroceptive sensing of the Drosophila leg. Nat. Commun. 16, 4105 (2025).
Hooper, S. L. et al. Neural control of unloaded leg posture and of leg swing in stick insect, cockroach, and mouse differs from that in larger animals. J. Neurosci. 29, 4109–4119 (2009).
Ache, J. M. & Matheson, T. Passive joint forces are tuned to limb use in insects and drive movements without motor activity. Curr. Biol. 23, 1418–1426 (2013).
Harris, R. M., Pfeiffer, B. D., Rubin, G. M. & Truman, J. W. Neuron hemilineages provide the functional ground plan for the Drosophila ventral nervous system. eLife 4, e04493 (2015).
Lacin, H. et al. Neurotransmitter identity is acquired in a lineage-restricted manner in the Drosophila CNS. eLife 8, e43701 (2019).
Tuthill, J. C. & Wilson, R. I. Mechanosensation and adaptive motor control in insects. Curr. Biol. 26, R1022–R1038 (2016).
Sapkal, N. et al. Neural circuit mechanisms underlying context-specific halting in Drosophila. Nature 634, 191–200 (2024).
Yang, H. H. et al. Fine-grained descending control of steering in walking Drosophila. Cell 187, 6290–6308 (2024).
Rayshubskiy, A. et al. Neural circuit mechanisms for steering control in walking Drosophila. eLife 13, RP102230 (2025).
Guo, L., Zhang, N. & Simpson, J. H. Descending neurons coordinate anterior grooming behavior in Drosophila. Curr. Biol. 32, 823–833 (2022).
Cheong, H. S. J. et al. Transforming descending input into behavior: the organization of premotor circuits in the Drosophila male adult nerve cord connectome. eLife 13, RP96084 (2024).
Sterne, G. R., Otsuna, H., Dickson, B. J. & Scott, K. Classification and genetic targeting of cell types in the primary taste and premotor center of the adult Drosophila brain. eLife 10, e71679 (2021).
Zheng, Z. et al. A complete electron microscopy volume of the brain of adult Drosophila melanogaster. Cell 174, 730–743 (2018).
Dorkenwald, S. et al. Neuronal wiring diagram of an adult brain. Nature 634, 124–138 (2024).
Schlegel, P. et al. Whole-brain annotation and multi-connectome cell typing of Drosophila. Nature 634, 139–152 (2024).
Emanuel, S., Kaiser, M., Pflueger, H.-J. & Libersat, F. On the role of the head ganglia in posture and walking in insects. Front. Physiol. 11, 135 (2020).
Shiu, P. K. et al. A Drosophila computational brain model reveals sensorimotor processing. Nature 634, 210–219 (2024).
Burrows, M. & Laurent, G. Synaptic potentials in the central terminals of locust proprioceptive afferents generated by other afferents from the same sense organ. J. Neurosci. 13, 808–819 (1993).
Burrows, M. & Matheson, T. A presynaptic gain control mechanism among sensory neurons of a locust leg proprioceptor. J. Neurosci. 14, 272–282 (1994).
Sauer, A. E., Büschges, A. & Stein, W. Role of presynaptic inputs to proprioceptive afferents in tuning sensorimotor pathways of an insect joint control network. J. Neurobiol. 32, 359–376 (1997).
Gebehart, C. & Büschges, A. The processing of proprioceptive signals in distributed networks: insights from insect motor control. J. Exp. Biol. 227, jeb246182 (2024).
Ramirez, J.-M., Büschges, A. & Kittmann, R. Octopaminergic modulation of the femoral chordotonal organ in the stick insect. J. Comp. Physiol. A 173, 209–219 (1993).
Matheson, T. Octopamine modulates the responses and presynaptic inhibition of proprioceptive sensory neurones in the locust Schistocerca gregaria. J. Exp. Biol. 200, 1317–1325 (1997).
Bässler, U. The femur-tibia control system of stick insects: a model system for the study of the neural basis of joint control. Brain Res. Rev. 18, 207–226 (1993).
Dean, J. Control of leg protraction in the stick insect: a targeted movement showing compensation for externally applied forces. J. Comp. Physiol. A 155, 771–781 (1984).
Takeoka, A., Vollenweider, I., Courtine, G. & Arber, S. Muscle spindle feedback directs locomotor recovery and circuit reorganization after spinal cord injury. Cell 159, 1626–1639 (2014).
Mayer, W. P. & Akay, T. The role of muscle spindle feedback in the guidance of hindlimb movement by the ipsilateral forelimb during locomotion in mice. eNeuro 8, ENEURO.0432-21.2021 (2021).
Mackrous, I., Carriot, J. & Cullen, K. E. Context-independent encoding of passive and active self-motion in vestibular afferent fibers during locomotion in primates. Nat. Commun. 13, 120 (2022).
Seki, K., Perlmutter, S. I. & Fetz, E. E. Sensory input to primate spinal cord is presynaptically inhibited during voluntary movement. Nat. Neurosci. 6, 1309–1316 (2003).
Tomatsu, S., Kim, G., Kubota, S. & Seki, K. Presynaptic gating of monkey proprioceptive signals for proper motor action. Nat. Commun. 14, 6537 (2023).
Pichler, P. & Lagnado, L. Motor behavior selectively inhibits hair cells activated by forward motion in the lateral line of zebrafish. Curr. Biol. 30, 150–157 (2020).
Odstrcil, I. et al. Functional and ultrastructural analysis of reafferent mechanosensation in larval zebrafish. Curr. Biol. 32, 176–189 (2022).
Wallach, A. & Sawtell, N. B. An internal model for canceling self-generated sensory input in freely behaving electric fish. Neuron 111, 2570–2582 (2023).
Poulet, J. F. A. & Hedwig, B. The cellular basis of a corollary discharge. Science 311, 518–522 (2006).
Gisselmann, G., Plonka, J., Pusch, H. & Hatt, H. Drosophila melanogaster GRD and LCCH3 subunits form heteromultimeric GABA‐gated cation channels. Br. J. Pharmacol. 142, 409–413 (2004).
Bogovic, J. A. et al. An unbiased template of the Drosophila brain and ventral nerve cord. PLoS ONE 15, e0236495 (2020).
Schindelin, J. et al. Fiji: an open-source platform for biological-image analysis. Nat. Methods 9, 676–682 (2012).
Jenett, A. et al. A GAL4-driver line resource for Drosophila neurobiology. Cell Rep. 2, 991–1001 (2012).
Meissner, G. W. et al. A searchable image resource of Drosophila GAL4 driver expression patterns with single neuron resolution. eLife 12, e80660 (2023).
Davie, K. et al. A single-cell transcriptome atlas of the aging Drosophila brain. Cell 174, 982–998 (2018).
Chen, C.-L. et al. Imaging neural activity in the ventral nerve cord of behaving adult Drosophila. Nat. Commun. 9, 4390 (2018).
Hermans, L. et al. Microengineered devices enable long-term imaging of the ventral nerve cord in behaving adult Drosophila. Nat. Commun. 13, 5006 (2022).
Moore, R. J. D. et al. FicTrac: a visual method for tracking spherical motion and generating fictive animal paths. J. Neurosci. Methods 225, 106–119 (2014).
Mathis, A. et al. DeepLabCut: markerless pose estimation of user-defined body parts with deep learning. Nat. Neurosci. 21, 1281–1289 (2018).
Karashchuk, P. et al. Anipose: a toolkit for robust markerless 3D pose estimation. Cell Rep. 36, 109730 (2021).
Guizar-Sicairos, M., Thurman, S. T. & Fienup, J. R. Efficient subpixel image registration algorithms. Opt. Lett. 33, 156–158 (2008).
Weir, P. T. & Dickinson, M. H. Functional divisions for visual processing in the central brain of flying Drosophila. Proc. Natl Acad. Sci. USA 112, E5523–E5532 (2015).
Azevedo, A. W. et al. A size principle for recruitment of Drosophila leg motor neurons. eLife 9, e56754 (2020).
Klapoetke, N. C. et al. Independent optical excitation of distinct neural populations. Nat. Methods 11, 338–346 (2014).
Mohammad, F. et al. Optogenetic inhibition of behavior with anion channelrhodopsins. Nat. Methods 14, 271–274 (2017).
Govorunova, E. G., Sineshchekov, O. A., Janz, R., Liu, X. & Spudich, J. L. Natural light-gated anion channels: a family of microbial rhodopsins for advanced optogenetics. Science 349, 647–650 (2015).
Pratt, B. G., Lee, S.-Y. J., Chou, G. M. & Tuthill, J. C. Miniature linear and split-belt treadmills reveal mechanisms of adaptive motor control in walking Drosophila. Curr. Biol. 34, 4368–4381 (2024).
Phelps, J. S. et al. Reconstruction of motor control circuits in adult Drosophila using automated transmission electron microscopy. Cell 184, 759–774 (2021).
Dorkenwald, S. et al. CAVE: Connectome Annotation Versioning Engine. Nat. Methods 22, 1112–1120 (2025).
Eckstein, N. et al. Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster. Cell 187, 2574–2594 (2024).
Stürner, T. et al. Comparative connectomics of Drosophila descending and ascending neurons. Nature 643, 158–172 (2025).
Lesser, E. et al. Synaptic architecture of leg and wing premotor control networks in Drosophila. Nature 631, 369–377 (2024).
Plaza, S. M. et al. neuPrint: an open access tool for EM connectomics. Front. Neuroinform. 16, 896292 (2022).
Dallmann, C. J. et al. Data from: Selective presynaptic inhibition of leg proprioception in behaving Drosophila. Dryad https://doi.org/10.5061/dryad.gqnk98t16 (2025).
Buhmann, J. et al. Automatic detection of synaptic partners in a whole-brain Drosophila electron microscopy data set. Nat. Methods 18, 771–774 (2021).
