Saturday, December 28, 2024
No menu items!
HomeNaturePrefrontal transthalamic uncertainty processing drives flexible switching

Prefrontal transthalamic uncertainty processing drives flexible switching

  • Purcell, B. A. & Kiani, R. Hierarchical decision processes that operate over distinct timescales underlie choice and changes in strategy. Proc. Natl Acad. Sci. USA 113, E4531–E4540 (2016).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Donoso, M., Collins, A. G. E. & Koechlin, E. Foundations of human reasoning in the prefrontal cortex. Science 344, 1481–1486 (2014).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar
     

  • Rigotti, M. The importance of mixed selectivity in complex cognitive tasks. Nature 497, 585–590 (2013).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Rushworth, M. F. S. & Behrens, T. E. J. Choice, uncertainty and value in prefrontal and cingulate cortex. Nat. Neurosci. 11, 389–397 (2008).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Tervo, D. G. R. et al. The anterior cingulate cortex directs exploration of alternative strategies. Neuron 109, 1876–1887.e6 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Botvinick, M., Nystrom, L. E., Fissell, K., Carter, C. S. & Cohen, J. D. Conflict monitoring versus selection-for-action in anterior cingulate cortex. Nature 402, 179–181 (1999).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar
     

  • Wallis, J. D., Anderson, K. C. & Miller, E. K. Single neurons in prefrontal cortex encode abstract roles. Nature 411, 953–956 (2001).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar
     

  • Ma, W. J. & Jazayeri, M. Neural coding of uncertainty and probability. Annu. Rev. Neurosci. 37, 205–220 (2014).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Koblinger, Á., Fiser, J. & Lengyel, M. Representations of uncertainty: where art thou? Curr. Opin. Behav. Sci. 38, 150–162 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sarafyadz, M. & Jazayeri, M. Hierarchical reasoning by neural circuits in the frontal cortex. Science 364, eaav8911 (2019).

    Article 

    Google Scholar
     

  • Ernst, M. O. & Banks, M. S. Humans integrate visual and haptic information in a statistically optimal fashion. Nature 415, 429–433 (2002).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar
     

  • Körding, K. P. & Wolpert, D. M. Bayesian integration in sensorimotor learning. Nature 427, 244–247 (2004).

    Article 
    ADS 
    PubMed 

    Google Scholar
     

  • Yoshida, W. & Ishii, S. Resolution of uncertainty in prefrontal cortex. Neuron 50, 781–789 (2006).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zylberberg, A., Wolpert, D. M. & Shadlen, M. N. Counterfactual reasoning underlies the learning of priors in decision making. Neuron 99, 1083–1097.e6 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Rushworth, M. F. S., Noonan, M. A. P., Boorman, E. D., Walton, M. E. & Behrens, T. E. Frontal cortex and reward-guided learning and decision-making. Neuron 70, 1054–1069 (2011).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Hanganu-Opatz, I. L. et al. Resolving the prefrontal mechanisms of adaptive cognitive behaviors: a cross-species perspective. Neuron 111, 1020–1036 (2023).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Halassa, M. M. & Kastner, S. Thalamic functions in distributed cognitive control. Nat. Neurosci. 20, 1669–1679 (2017).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • DeNicola, A. L., Park, M. Y., Crowe, D. A., MacDonald, A. W. & Chafee, M. V. Differential roles of mediodorsal nucleus of the thalamus and prefrontal cortex in decision-making and state representation in a cognitive control task measuring deficits in schizophrenia. J. Neurosci. 40, 1650–1667 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bolkan, S. S. et al. Thalamic projections sustain prefrontal activity during working memory maintenance. Nat. Neurosci. 20, 987–996 (2017).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Shine, J. M., Lewis, L. D., Garrett, D. D. & Hwang, K. The impact of the human thalamus on brain-wide information processing. Nat. Rev. Neurosci. 24, 416–430 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Schmitt, L. I. et al. Thalamic amplification of cortical connectivity sustains attentional control. Nature 545, 219–223 (2017).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mukherjee, A., Lam, N. H., Wimmer, R. D. & Halassa, M. M. Thalamic circuits for independent control of prefrontal signal and noise. Nature 600, 100–104 (2021).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Grinband, J., Hirsch, J. & Ferrera, V. P. A neural representation of categorization uncertainty in the human brain. Neuron 49, 757–763 (2006).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Parnaudeau, S. et al. Inhibition of mediodorsal thalamus disrupts thalamofrontal connectivity and cognition. Neuron 77, 1151–1162 (2013).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chakraborty, S., Kolling, N., Walton, M. E. & Mitchell, A. S. Critical role for the mediodorsal thalamus in permitting rapid reward-guided updating in stochastic reward environments. eLife 5, e13588 (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Alcaraz, F. et al. Thalamocortical and corticothalamic pathways differentially contribute to goal-directed behaviors in the rat. eLife 7, e32517 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Li, C., McHaney, K. M., Sederberg, P. B. & Cang, J. Tree shrews as an animal model for studying perceptual decision-making reveal a critical role of stimulus-independent processes in guiding behavior. eNeuro 9, ENEURO.0419-22.2022 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Schumacher, J. W., McCann, M. K., Maximov, K. J. & Fitzpatrick, D. Selective enhancement of neural coding in V1 underlies fine-discrimination learning in tree shrew. Curr. Biol. 32, 3245–3260.e5 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hoover, W. B. & Vertes, R. P. Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat. Brain Struct. Funct. 212, 149–179 (2007).

    Article 
    PubMed 

    Google Scholar
     

  • Vertes, R. P., Palomero-Gallagher, N. & Halassa, M. M. in The Frontal Cortex: Organization, Networks, and Function Vol. 35 (eds Banich, M. T. et al.) Ch. 3 (MIT Press, 2024).

  • Goldman‐Rakic, P. S. & Porrino, L. J. The primate mediodorsal (MD) nucleus and its projection to the frontal lobe. J. Comp. Neurol. 242, 535–560 (1985).

    Article 
    PubMed 

    Google Scholar
     

  • Wong, P. & Kaas, J. H. Architectonic subdivisions of neocortex in the tree shrew (Tupaia belangeri). Anat. Rec. 292, 994 (2009).

    Article 

    Google Scholar
     

  • Zilles, K. & Palomero-Gallagher, N. Comparative analysis of receptor types that identify primary cortical sensory areas. Evol. Nerv. Syst. 2–4, 225–245 (2017).

    Article 

    Google Scholar
     

  • Goldring, A. B. & Krubitzer, L. A. in Evolutionary Neuroscience (ed. Kaas, J. H.) 627–656 (Academic Press, 2020).

  • Lee, K. S., Huang, X. & Fitzpatrick, D. Topology of on and off inputs in visual cortex enables an invariant columnar architecture. Nature 533, 90–94 (2016).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Casaorande, V. A., Harting, J. K., Hall, W. C., Diamond, I. T. & Martin, G. F. Superior colliculus of the tree shrew: a structural and functional subdivision into superficial and deep layers. Science 177, 444–447 (1972).

    Article 
    ADS 

    Google Scholar
     

  • Mante, V., Sussillo, D., Shenoy, K. V. & Newsome, W. T. Context-dependent computation by recurrent dynamics in prefrontal cortex. Nature 503, 78–84 (2013).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Akam, T. et al. The anterior cingulate cortex predicts future states to mediate model-based action selection. Neuron 109, 149–163.e7 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hayden, B. Y., Heilbronner, S. R., Pearson, J. M. & Platt, M. L. Surprise signals in anterior cingulate cortex: neuronal encoding of unsigned reward prediction errors driving adjustment in behavior. J. Neurosci. 31, 4178–4187 (2011).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Vertechi, P. et al. Inference-based decisions in a hidden state foraging task: differential contributions of prefrontal cortical areas. Neuron 106, 166–176.e6 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Phillips, J. M. et al. Topographic organization of connections between prefrontal cortex and mediodorsal thalamus: evidence for a general principle of indirect thalamic pathways between directly connected cortical areas. Neuroimage 189, 832 (2019).

    Article 
    PubMed 

    Google Scholar
     

  • Mukherjee, A. et al. Variation of connectivity across exemplar sensory and associative thalamocortical loops in the mouse. eLife 9, e62554 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Srinath, R., Ruff, D. A. & Cohen, M. R. Attention improves information flow between neuronal populations without changing the communication subspace. Curr. Biol. 31, 5299–5313.e4 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Semedo, J. D., Zandvakili, A., Machens, C. K., Yu, B. M. & Kohn, A. Cortical areas interact through a communication subspace. Neuron 102, 249–259.e4 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wilson, R. C. & Collins, A. G. E. Ten simple rules for the computational modeling of behavioral data. eLife 8, e49547 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Aoi, M. C., Mante, V. & Pillow, J. W. Prefrontal cortex exhibits multidimensional dynamic encoding during decision-making. Nat. Neurosci. 23, 1410–1420 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Rikhye, R. V., Gilra, A. & Halassa, M. M. Thalamic regulation of switching between cortical representations enables cognitive flexibility. Nat. Neurosci. 21, 1753–1763 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kobak, D. et al. Demixed principal component analysis of neural population data. eLife 5, e10989 (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kosciessa, J. Q., Lindenberger, U. & Garrett, D. D. Thalamocortical excitability modulation guides human perception under uncertainty. Nat. Commun. 12, 2430 (2021).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Li, Y. S., Nassar, M. R., Kable, J. W. & Gold, J. I. Individual neurons in the cingulate cortex encode action monitoring, not selection, during adaptive decision-making. J. Neurosci. 39, 6668–6683 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Komura, Y., Nikkuni, A., Hirashima, N., Uetake, T. & Miyamoto, A. Responses of pulvinar neurons reflect a subject’s confidence in visual categorization. Nat. Neurosci. 16, 749–755 (2013).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Hwang, K., Shine, J. M., Cole, M. W. & Sorenson, E. Thalamocortical contributions to cognitive task activity. eLife 11, e81282 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Halassa, M. M. & Sherman, S. M. Thalamocortical circuit motifs: a general framework. Neuron 103, 762–770 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zheng, W.-L., Wu, Z., Hummos, A., Yang, G. R. & Halassa, M. M. Rapid context inference in a thalamocortical model using recurrent neural networks. Nat. Commun. 15, 8275 (2024).

  • Wolff, M. & Halassa, M. M. The mediodorsal thalamus in executive control. Neuron 112, 893–908 (2024).

  • Scott, D. N., Mukherjee, A., Nassar, M. R. & Halassa, M. M. Thalamocortical architectures for flexible cognition and efficient learning. Trends Cogn. Sci. 28, 739–756 (2024).

    Article 
    PubMed 

    Google Scholar
     

  • Kreis, I., Zhang, L., Moritz, S. & Pfuhl, G. Spared performance but increased uncertainty in schizophrenia: Evidence from a probabilistic decision-making task. Schizophr. Res. 243, 4414–423 (2022).

    Article 

    Google Scholar
     

  • Cole, D. M. et al. Atypical processing of uncertainty in individuals at risk for psychosis. Neuroimage Clin. 26, 102239 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Nassar, M., Waltz, J., Albrecht, M., Gold, J. & Frank, M. All or nothing belief updating in patients with schizophrenia reduces precision and flexibility of beliefs. Brain 144, 1013–1029 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cascella, N. et al. Deep brain stimulation of the substantia nigra pars reticulata for treatment-resistant schizophrenia: a case report. Biol. Psychiatry 90, e57–e59 (2021).

    Article 
    PubMed 

    Google Scholar
     

  • Wimmer, R. D. et al. Thalamic control of sensory selection in divided attention. Nature 526, 705–709 (2015).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Brunetti, M. et al. Design and fabrication of ultralight weight, adjustable multi-electrode probes for electrophysiological recordings in mice. J.Vis. Exp. https://doi.org/10.3791/51675-v (2014).

  • Zhou, J.-N. & Ni, R.-J. The Tree Shrew (Tupaia belangeri chinensis) Brain in Stereotaxic Coordinates 1st edn (Springer, 2016).

  • Franklin, K. B. J. & Paxinos, G. The Mouse Brain in Stereotaxic Coordinates 3rd edn (Elsevier, 2008).

  • Daw, N. D., O’Doherty, J. P., Dayan, P., Seymour, B. & Dolan, R. J. Cortical substrates for exploratory decisions in humans. Nature 441, 876 (2006).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bolkan, S. S. et al. Opponent control of behavior by dorsomedial striatal pathways depends on task demands and internal state. Nat. Neurosci. 25, 345–357 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lundqvist, M. et al. Gamma and beta bursts underlie working memory. Neuron 90, 152–164 (2016).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Meyers, E. M. The neural decoding toolbox. Front. Neuroinform. 7, 8 (2013).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Pillow, J. W. et al. Spatio-temporal correlations and visual signalling in a complete neuronal population. Nature 454, 995–999 (2008).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • RELATED ARTICLES

    Most Popular

    Recent Comments