Zeng, Q. et al. Synaptic proximity enables NMDAR signalling to promote brain metastasis. Nature 573, 526–531 (2019).
Venkatesh, H. S. et al. Electrical and synaptic integration of glioma into neural circuits. Nature 573, 539–545 (2019).
Venkataramani, V. et al. Glutamatergic synaptic input to glioma cells drives brain tumour progression. Nature 573, 532–538 (2019).
Hanahan, D. & Monje, M. Cancer hallmarks intersect with neuroscience in the tumor microenvironment. Cancer Cell 41, 573–580 (2023).
Venkataramani, V. et al. Glioblastoma hijacks neuronal mechanisms for brain invasion. Cell 185, 2899–2917 (2022).
Krishna, S. et al. Glioblastoma remodelling of human neural circuits decreases survival. Nature 617, 599–607 (2023).
Hyman, S. E. Neurotransmitters. Curr. Biol. 15, R154–R158 (2005).
Balood, M. et al. Nociceptor neurons affect cancer immunosurveillance. Nature 611, 405–412 (2022).
Zhang, Y. et al. Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies. Cell Metab. 34, 1999–2017.e10 (2022).
Reavis, H. D., Chen, H. I. & Drapkin, R. Tumor innervation: cancer has some nerve. Trends Cancer 6, 1059–1067 (2020).
Zhao, C. M. et al. Denervation suppresses gastric tumorigenesis. Sci. Transl. Med. 6, 250ra115 (2014).
Berthoud, H. R. & Neuhuber, W. L. Functional and chemical anatomy of the afferent vagal system. Auton. Neurosci. 85, 1–17 (2000).
Hayakawa, Y. et al. Nerve growth factor promotes gastric tumorigenesis through aberrant cholinergic signaling. Cancer Cell 31, 21–34 (2017).
Chang, W. et al. Hormonal suppression of stem cells inhibits symmetric cell division and gastric tumorigenesis. Cell Stem Cell 26, 739–754 (2020).
Till, J. E. et al. Oncogenic KRAS and p53 loss drive gastric tumorigenesis in mice that can be attenuated by E-cadherin expression. Cancer Res. 77, 5349–5359 (2017).
Ma, L., Lei, L., Eng, S. R., Turner, E. & Parada, L. F. Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons. Development 130, 3525–3534 (2003).
Lee, S. et al. NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma. Nat. Commun. 12, 4939 (2021).
Ji, R. R., Samad, T. A., Jin, S. X., Schmoll, R. & Woolf, C. J. p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. Neuron 36, 57–68 (2002).
Hayakawa, Y. et al. Mist1 expressing gastric stem cells maintain the normal and neoplastic gastric epithelium and are supported by a perivascular stem cell niche. Cancer Cell 28, 800–814 (2015).
Ahluwalia, A. et al. Reduced NGF in gastric endothelial cells is one of the main causes of impaired angiogenesis in aging gastric mucosa. Cell. Mol. Gastroenterol. Hepatol. 6, 199–213 (2018).
Callaway, E. M. & Luo, L. Monosynaptic circuit tracing with glycoprotein-deleted rabies viruses. J. Neurosci. 35, 8979–8985 (2015).
Russell, F. A., King, R., Smillie, S. J., Kodji, X. & Brain, S. D. Calcitonin gene-related peptide: physiology and pathophysiology. Physiol. Rev. 94, 1099–1142 (2014).
Kim, Y. J. & Granstein, R. D. Roles of calcitonin gene-related peptide in the skin, and other physiological and pathophysiological functions. Brain Behav. Immun. Health 18, 100361 (2021).
Yang, D. et al. Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection. Cell 185, 4190–4205 (2022).
Horie, S., Michael, G. J. & Priestley, J. V. Co-localization of TRPV1-expressing nerve fibers with calcitonin-gene-related peptide and substance P in fundus of rat stomach. Inflammopharmacology 13, 127–137 (2005).
Okabe, S. & Amagase, K. An overview of acetic acid ulcer models-the history and state of the art of peptic ulcer research. Biol. Pharm. Bull. 28, 1321–1341 (2005).
Lai, N. Y. et al. Gut-innervating nociceptor neurons regulate peyer’s patch microfold cells and SFB levels to mediate Salmonella host defense. Cell 180, 33–49 (2020).
Le, T. T. et al. Sensory nerves enhance triple-negative breast cancer invasion and metastasis via the axon guidance molecule PlexinB3. npj Breast Cancer 8, 116 (2022).
Filliol, A. et al. Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis. Nature 610, 356–365 (2022).
Carr, R. & Frings, S. Neuropeptides in sensory signal processing. Cell Tissue Res. 375, 217–225 (2019).
Bocchi, R., Masserdotti, G. & Gotz, M. Direct neuronal reprogramming: fast forward from new concepts toward therapeutic approaches. Neuron 110, 366–393 (2022).
Vermeiren, S., Bellefroid, E. J. & Desiderio, S. Vertebrate sensory ganglia: common and divergent features of the transcriptional programs generating their functional specialization. Front. Cell Dev. Biol. 8, 587699 (2020).
Tomlinson, R. E. et al. NGF-TrkA signaling in sensory nerves is required for skeletal adaptation to mechanical loads in mice. Proc. Natl Acad. Sci. USA 114, E3632–E3641 (2017).
Umoh, N. A. et al. Calcitonin gene-related peptide regulates cardiomyocyte survival through regulation of oxidative stress by PI3K/Akt and MAPK signaling pathways. Ann. Clin. Exp. Hypertens. 2, 1007 (2014).
Venkatesh, H. S. et al. Neuronal activity promotes glioma growth through neuroligin-3 secretion. Cell 161, 803–816 (2015).
Peterson, S. C. et al. Basal cell carcinoma preferentially arises from stem cells within hair follicle and mechanosensory niches. Cell Stem Cell 16, 400–412 (2015).
Saloman, J. L. et al. Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer. Proc. Natl Acad. Sci. USA 113, 3078–3083 (2016).
Restaino, A. C. et al. Functional neuronal circuits promote disease progression in cancer. Sci. Adv. 9, eade4443 (2023).
Zhong, F., Christianson, J. A., Davis, B. M. & Bielefeldt, K. Dichotomizing axons in spinal and vagal afferents of the mouse stomach. Dig. Dis. Sci. 53, 194–203 (2008).
Lobikin, M., Chernet, B., Lobo, D. & Levin, M. Resting potential, oncogene-induced tumorigenesis, and metastasis: the bioelectric basis of cancer in vivo. Phys. Biol. 9, 065002 (2012).
Yang, M. & Brackenbury, W. J. Membrane potential and cancer progression. Front. Physiol. 4, 185 (2013).
Lukyanetz, E. A. Different secretory vesicles can be involved in depolarization-evoked exocytosis. Biochem. Biophys. Res. Commun. 288, 844–848 (2001).
Bohorquez, D. V. et al. Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells. J. Clin. Invest. 125, 782–786 (2015).
Zhang, W. et al. Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection. Cell 185, 4170–4189 (2022).
Gao, X. et al. Nociceptive nerves regulate haematopoietic stem cell mobilization. Nature 589, 591–596 (2021).
McIlvried, L. A., Atherton, M. A., Horan, N. L., Goch, T. N. & Scheff, N. N. Sensory neurotransmitter calcitonin gene-related peptide modulates tumor growth and lymphocyte infiltration in oral squamous cell carcinoma. Adv. Biol. 6, e2200019 (2022).
Edvinsson, L., Haanes, K. A., Warfvinge, K. & Krause, D. N. CGRP as the target of new migraine therapies—successful translation from bench to clinic. Nat. Rev. Neurol. 14, 338–350 (2018).
Elser, H. et al. Cancer risk in patients with migraine: a population-based cohort study in Denmark. Headache 62, 57–64 (2022).
Hayakawa, Y. et al. BHLHA15-positive secretory precursor cells can give rise to tumors in intestine and colon in mice. Gastroenterology 156, 1066–1081 (2019).
Zhan, J., Komal, R., Keenan, W. T., Hattar, S. & Fernandez, D. C. Non-invasive strategies for chronic manipulation of DREADD-controlled neuronal activity. J. Vis. Exp. https://doi.org/10.3791/59439 (2019).
de Sousae Melo, F. et al. A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer. Nature 543, 676–680 (2017).
Ayer, A. et al. Techniques of sleeve gastrectomy and modified Roux-en-Y gastric bypass in mice. J. Vis. Exp. https://doi.org/10.3791/54905 (2017).
Kaelberer, M. M. et al. A gut-brain neural circuit for nutrient sensory transduction. Science 361, eaat5236 (2018).
Wolf, F. A. et al. SCANPY: large-scale single-cell gene expression data analysis. Genome Biol. 19, 15 (2018).