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HomeSportsNFL picks 2025: Full list of Week 6 predictions with confidence levels

NFL picks 2025: Full list of Week 6 predictions with confidence levels

Welcome back for Week 6 of the 2025 NFL season! Last week was a wild one across the league with a huge amount of upsets. Nine underdogs won outright, including five of the six biggest underdogs. The Titans win over the Cardinals was a stunner given how far down Tennessee was, but the biggest upset of the week was probably the Patriots going into Buffalo and stunning the Bills in the closing seconds.

It’s no surprise that last week was a horrible week for my confidence picks. I went 6-10 overall, going 2-2 in high confidence picks, 1-2 in medium confidence picks, and 3-4 in low confidence. I went into the weekend thinking I was being too risky with my picks. Turns out I wasn’t taking enough risks!

The Week 6 slate features the biggest favorite of the season with the Packers sitting at -14.5 against the Bengals on Sunday afternoon. Apparently trading for Joe Flacco didn’t move the needle for Cincinnati. Who knew! The week opens with the Giants hosting the Eagles, and while New York is struggling, there’s a strong chance this game turns into a rock fight. The week closes with the Falcons hosting the Bills and the Commanders hosting the Bears in a Monday Night Football doubleheader. The best games of the week might be the 4-1 Bucs hosting the 4-1 49ers and the 4-1 Jaguars hosting the 3-2 Seahawks. But don’t sleep on Lions-Chiefs on Sunday Night Football. The Vikings and Texans are on bye.

Steelers over Browns
Rams over Ravens
Packers over Bengals

Chargers over Dolphins
Patriots over Saints
Colts over Cardinals
Cowboys over Panthers
Bills over Falcons

Eagles over Giants
Broncos over Jets
Jaguars over Seahawks
Raiders over Titans
49ers over Bucs***
Lions over Chiefs***
Commanders over Bears

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