MacDonald, C. J., Lepage, K. Q., Eden, U. T. & Eichenbaum, H. Hippocampal ‘time cells’ bridge the gap in memory for discontiguous events. Neuron 71, 737–749 (2011).
Gauthier, J. L. & Tank, D. W. A dedicated population for reward coding in the hippocampus. Neuron 99, 179–193.e7 (2018).
Aronov, D., Nevers, R. & Tank, D. W. Mapping of a non-spatial dimension by the hippocampal–entorhinal circuit. Nature 543, 719–722 (2017).
Manns, J. R., Howard, M. W. & Eichenbaum, H. Gradual changes in hippocampal activity support remembering the order of events. Neuron 56, 530–540 (2007).
Josselyn, S. A. & Tonegawa, S. Memory engrams: recalling the past and imagining the future. Science 367, eaaw4325 (2020).
Tuncdemir, S. N. et al. Parallel processing of sensory cue and spatial information in the dentate gyrus. Cell Rep. 38, 110257 (2022).
Purandare, C. & Mehta, M. Mega-scale movie-fields in the mouse visuo-hippocampal network. eLife 12, RP85069 (2023).
Radvansky, B. A., Oh, J. Y., Climer, J. R. & Dombeck, D. A. Behavior determines the hippocampal spatial mapping of a multisensory environment. Cell Rep. 36, 109444 (2021).
O’Keefe, J. & Krupic, J. Do hippocampal pyramidal cells respond to nonspatial stimuli? Physiol. Rev. 101, 1427–1456 (2021).
Eichenbaum, H. A cortical–hippocampal system for declarative memory. Nat. Rev. Neurosci. 1, 41–50 (2000).
Vanderwolf, C. H. Hippocampal electrical activity and voluntary movement in the rat. Electroencephalogr. Clin. Neurophysiol. 26, 407–418 (1969).
Arezzo, J. & Vaughan, H. G. Cortical potentials associated with voluntary movements in the monkey. Brain Res. 88, 99–104 (1975).
Numan, R. A prefrontal–hippocampal comparator for goal-directed behavior: the intentional self and episodic memory. Front. Behav. Neurosci. 9, 323 (2015).
Miller, E. K. & Cohen, J. D. An integrative theory of prefrontal cortex function. Annu. Rev. Neurosci. 24, 167–202 (2001).
Olton, D. S., Becker, J. T. & Handelmann, G. E. Hippocampal function: working memory or cognitive mapping? Physiol. Psychol. 8, 239–246 (1980).
McNaughton, B. L. et al. Deciphering the hippocampal polyglot: the hippocampus as a path integration system. J. Exp. Biol. 199, 173–185 (1996).
Stachenfeld, K. L., Botvinick, M. M. & Gershman, S. J. The hippocampus as a predictive map. Nat. Neurosci. 20, 1643–1653 (2017).
Buzsáki, G. & Moser, E. I. Memory, navigation and theta rhythm in the hippocampal–entorhinal system. Nat. Neurosci. 16, 130–138 (2013).
Schiller, D. et al. Memory and space: towards an understanding of the cognitive map. J. Neurosci. 35, 13904–13911 (2015).
Lisman, J. et al. Viewpoints: how the hippocampus contributes to memory, navigation and cognition. Nat. Neurosci. 20, 1434–1447 (2017).
Huszár, R., Zhang, Y., Blockus, H. & Buzsáki, G. Preconfigured dynamics in the hippocampus are guided by embryonic birthdate and rate of neurogenesis. Nat. Neurosci. 25, 1201–1212 (2022).
Sosa, M., Plitt, M. H. & Giocomo, L. M. Hippocampal sequences span experience relative to rewards. Preprint at bioRxiv https://doi.org/10.1101/2023.12.27.573490 (2023).
Syed, E. C. J. et al. Action initiation shapes mesolimbic dopamine encoding of future rewards. Nat. Neurosci. 19, 34–36 (2015).
Bogacz, R. Dopamine role in learning and action inference. eLife 9, e53262 (2020).
Wikenheiser, A. M. & Redish, A. D. Hippocampal theta sequences reflect current goals. Nat. Neurosci. 18, 289–294 (2015).
Kay, K. et al. Constant sub-second cycling between representations of possible futures in the hippocampus. Cell 180, 552–567.e25 (2020).
Sun, C., Yang, W., Martin, J. & Tonegawa, S. Hippocampal neurons represent events as transferable units of experience. Nat. Neurosci. 23, 651–663 (2020).
Nieh, E. H. et al. Geometry of abstract learned knowledge in the hippocampus. Nature 595, 80–84 (2021).
Muller, R. U. & Kubie, J. L. The effects of changes in the environment on the spatial firing of hippocampal complex-spike cells. J. Neurosci. 7, 1951–1968 (1987).
Hales, J. B. et al. Medial entorhinal cortex lesions only partially disrupt hippocampal place cells and hippocampus-dependent place memory. Cell Rep. 9, 893–901 (2014).
Ormond, J., McNaughton, B. L. & Moser, E. I. Place field expansion after focal MEC inactivations is consistent with loss of Fourier components and path integrator gain reduction. Proc. Natl Acad. Sci. USA 112, 4116–4121 (2015).
Robinson, N. T. M. et al. Medial entorhinal cortex selectively supports temporal coding by hippocampal neurons. Neuron 94, 677–688.e6 (2017).
Zutshi, I., Valero, M., Fernández-Ruiz, A. & Buzsáki, G. Extrinsic control and intrinsic computation in the hippocampal CA1 circuit. Neuron 110, 658–673.e5 (2022).
Pastalkova, E., Itskov, V., Amarasingham, A. & Buzsáki, G. Internally generated cell assembly sequences in the rat hippocampus. Science 321, 1322–1327 (2008).
Green, L., Tingley, D., Rinzel, J. & Buzsáki, G. Action-driven remapping of hippocampal neuronal populations in jumping rats. Proc. Natl Acad. Sci. USA 119, e2122141119 (2022).
Diba, K. & Buzsáki, G. Hippocampal network dynamics constrain the time lag between pyramidal cells across modified environments. J. Neurosci. 28, 13448–13456 (2008).
Muzzio, I. A. et al. Attention enhances the retrieval and stability of visuospatial and olfactory representations in the dorsal hippocampus. PLoS Biol. 7, e1000140 (2009).
Jackson, J. & Redish, A. D. Network dynamics of hippocampal cell-assemblies resemble multiple spatial maps within single tasks. Hippocampus 17, 1209–1229 (2007).
Fenton, A. A. & Muller, R. U. Place cell discharge is extremely variable during individual passes of the rat through the firing field. Proc. Natl Acad. Sci. USA 95, 3182–3187 (1998).
Kentros, C. G., Agnihotri, N. T., Streater, S., Hawkins, R. D. & Kandel, E. R. Increased attention to spatial context increases both place field stability and spatial memory. Neuron 42, 283–295 (2004).
Frank, L. M., Brown, E. N. & Wilson, M. Trajectory encoding in the hippocampus and entorhinal cortex. Neuron 27, 169–178 (2000).
Wood, E. R., Dudchenko, P. A., Robitsek, R. J. & Eichenbaum, H. Hippocampal neurons encode information about different types of memory episodes occurring in the same location. Neuron 27, 623–633 (2000).
Whittington, J. C. R. et al. The Tolman–Eichenbaum machine: unifying space and relational memory through generalization in the hippocampal formation. Cell 183, 1249–1263.e23 (2020).
El-Gaby, M. et al. A cellular basis for mapping behavioural structure. Nature https://doi.org/10.1038/s41586-024-08145-x (2024).
Villette, V., Malvache, A., Tressard, T., Dupuy, N. & Cossart, R. Internally recurring hippocampal sequences as a population template of spatiotemporal information. Neuron 88, 357–366 (2015).
Buzsáki, G. & Tingley, D. Space and time: the hippocampus as a sequence generator. Trends Cogn. Sci. 22, 853–869 (2018).
Liberti, W. A., Schmid, T. A., Forli, A., Snyder, M. & Yartsev, M. M. A stable hippocampal code in freely flying bats. Nature 604, 98–103 (2022).
Schacter, D. L. & Addis, D. R. On the nature of medial temporal lobe contributions to the constructive simulation of future events. Phil. Trans. R. Soc. B 364, 1245–1253 (2009).
Wikenheiser, A. M. & Redish, A. D. Decoding the cognitive map: ensemble hippocampal sequences and decision making. Curr. Opin. Neurobiol. https://doi.org/10.1016/j.conb.2014.10.002 (2014).
Hok, V. et al. Goal-related activity in hippocampal place cells. J. Neurosci. 27, 472–482 (2007).
Tyler, E. & Kravitz, L. Walking mouse. Zenodo https://doi.org/10.5281/zenodo.3925915 (2020).
Vöröslakos, M., Petersen, P. C., Vöröslakos, B. & Buzsáki, G. Metal microdrive and head cap system for silicon probe recovery in freely moving rodent. eLife 10, e65859 (2021).
Pachitariu, M., Steinmetz, N., Kadir, S., Carandini, M. & Harris, K. Fast and accurate spike sorting of high-channel count probes with KiloSort. In Proc. 30th International Conference on Neural Information Processing Systems Vol. 29 (eds Lee, D. D. et al.) 4455–4463 (Curran Associates, 2016).
Petersen, P. C., Siegle, J. H., Steinmetz, N. A., Mahallati, S. & Buzsáki, G. CellExplorer: a framework for visualizing and characterizing single neurons. Neuron 109, 3594–3608.e2 (2021).
Balzani, E., Lakshminarasimhan, K., Angelaki, D. E. & Savin, C. Efficient estimation of neural tuning during naturalistic behavior. In Proc. 34th International Conference on Neural Information Processing Systems (eds Larochelle, H. et al.) 1057 (Curran Associates, 2020).
Noel, J. P. et al. Coding of latent variables in sensory, parietal, and frontal cortices during closed-loop virtual navigation. eLife 11, e80280 (2022).
Singh, D. & Singh, B. Investigating the impact of data normalization on classification performance. Appl. Soft Comput. 97, 105524 (2020).
Lopes-dos-Santos, V., Ribeiro, S. & Tort, A. B. L. Detecting cell assemblies in large neuronal populations. J. Neurosci. Methods 220, 149–166 (2013).
van de Ven, G. M., Trouche, S., McNamara, C. G., Allen, K. & Dupret, D. Hippocampal offline reactivation consolidates recently formed cell assembly patterns during sharp wave-ripples. Neuron 92, 968–974 (2016).
Ritchey, M., Libby, L. A. & Ranganath, C. Cortico-hippocampal systems involved in memory and cognition: the PMAT framework. Prog. Brain Res. 219, 45–64 (2015).
Yang, W. et al. Selection of experience for memory by hippocampal sharp wave ripples. Science 383, 1478–1483 (2024).
McInnes, L., Healy, J., Saul, N. & Großberger, L. UMAP: uniform manifold approximation and projection. J. Open Source Softw. 3, 861 (2018).
Stringer, C. et al. Rastermap: a discovery method for neural population recordings. Nat. Neurosci. https://doi.org/10.1038/s41593-024-01783-4 (2024).
Johnson, A. & Redish, A. D. Neural ensembles in CA3 transiently encode paths forward of the animal at a decision point. J. Neurosci. 27, 12176–12189 (2007).
Johnson, A., Jackson, J. C. & Redish, A. D. in Information Processing by Neuronal Populations (eds Holscher, C. & Munk, M.) 95–119 (Cambridge Univ. Press, 2008).
Brown, E. N., Frank, L. M., Tang, D., Quirk, M. C. & Wilson, M. A. A statistical paradigm for neural spike train decoding applied to position prediction from ensemble firing patterns of rat hippocampal place cells. J. Neurosci. 18, 7411–7425 (1998).
Denovellis, E. L. et al. Hippocampal replay of experience at real-world speeds. eLife 10, e64505 (2021).
Killick, R., Fearnhead, P. & Eckley, I. A. Optimal detection of changepoints with a linear computational cost. J. Am. Stat. Assoc. 107, 1590–1598 (2012).
Zheng, Z. et al. Perpetual step-like restructuring of hippocampal circuit dynamics. Cell Rep. 43, 114702 (2024).
Hastie, T. & Tibshirani, R. Generalized additive models: some applications. J. Am. Stat. Assoc. 82, 371–386 (1987).
McKenzie, S. et al. Preexisting hippocampal network dynamics constrain optogenetically induced place fields. Neuron 109, 1040–1054.e7 (2021).
Senzai, Y., Fernandez-Ruiz, A. & Buzsáki, G. Layer-specific physiological features and interlaminar interactions in the primary visual cortex of the mouse. Neuron 101, 500–513.e5 (2019).
Valero, M. et al. Sleep down state-active ID2/Nkx2.1 interneurons in the neocortex. Nat. Neurosci. 24, 401–411 (2021).
Zhang, Y. et al. Cholinergic suppression of hippocampal sharp-wave ripples impairs working memory. Proc. Natl Acad. Sci. USA 118, e2016432118 (2021).
