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HomeNatureCDK5–cyclin B1 regulates mitotic fidelity

CDK5–cyclin B1 regulates mitotic fidelity

  • Wieser, S. & Pines, J. The biochemistry of mitosis. Cold Spring Harb. Perspect. Biol. 7, a015776 (2015).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Dhavan, R. & Tsai, L. H. A decade of CDK5. Nat. Rev. Mol. Cell Biol. 2, 749–759 (2001).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Malumbres, M. Cyclin-dependent kinases. Genome Biol. 15, 122 (2014).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Coverley, D., Laman, H. & Laskey, R. A. Distinct roles for cyclins E and A during DNA replication complex assembly and activation. Nat. Cell Biol. 4, 523–528 (2002).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Desai, D., Wessling, H. C., Fisher, R. P. & Morgan, D. O. Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2. Mol. Cell. Biol. 15, 345–350 (1995).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Brown, N. R. et al. CDK1 structures reveal conserved and unique features of the essential cell cycle CDK. Nat. Commun. 6, 6769 (2015).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Strauss, B. et al. Cyclin B1 is essential for mitosis in mouse embryos, and its nuclear export sets the time for mitosis. J. Cell Biol. 217, 179–193 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gavet, O. & Pines, J. Activation of cyclin B1-Cdk1 synchronizes events in the nucleus and the cytoplasm at mitosis. J. Cell Biol. 189, 247–259 (2010).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Barbiero, M. et al. Cell cycle-dependent binding between cyclin B1 and Cdk1 revealed by time-resolved fluorescence correlation spectroscopy. Open Biol. 12, 220057 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Pines, J. & Hunter, T. Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2. Cell 58, 833–846 (1989).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Clute, P. & Pines, J. Temporal and spatial control of cyclin B1 destruction in metaphase. Nat. Cell Biol. 1, 82–87 (1999).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Potapova, T. A. et al. The reversibility of mitotic exit in vertebrate cells. Nature 440, 954–958 (2006).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Basu, S., Greenwood, J., Jones, A. W. & Nurse, P. Core control principles of the eukaryotic cell cycle. Nature 607, 381–386 (2022).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Santamaria, D. et al. Cdk1 is sufficient to drive the mammalian cell cycle. Nature 448, 811–815 (2007).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar
     

  • Zheng, X. F. et al. A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1. Nat. Commun. 10, 4252 (2019).

    Article 
    ADS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Fagerberg, L. et al. Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics. Mol. Cell. Proteom. 13, 397–406 (2014).

    Article 
    CAS 

    Google Scholar
     

  • Pozo, K. & Bibb, J. A. The emerging role of Cdk5 in cancer. Trends Cancer 2, 606–618 (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sharma, S. & Sicinski, P. A kinase of many talents: non-neuronal functions of CDK5 in development and disease. Open Biol. 10, 190287 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sun, K. H. et al. Novel genetic tools reveal Cdk5’s major role in Golgi fragmentation in Alzheimer’s disease. Mol. Biol. Cell 19, 3052–3069 (2008).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sharma, S. et al. Targeting the cyclin-dependent kinase 5 in metastatic melanoma. Proc. Natl Acad. Sci. USA 117, 8001–8012 (2020).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Nabet, B. et al. The dTAG system for immediate and target-specific protein degradation. Nat. Chem. Biol. 14, 431–441 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Simpson, L. M. et al. Target protein localization and its impact on PROTAC-mediated degradation. Cell Chem. Biol. 29, 1482–1504 e1487 (2022).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Vassilev, L. T. et al. Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1. Proc. Natl Acad. Sci. USA 103, 10660–10665 (2006).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Janssen, A. F. J., Breusegem, S. Y. & Larrieu, D. Current methods and pipelines for image-based quantitation of nuclear shape and nuclear envelope abnormalities. Cells 11, 347 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Thompson, S. L. & Compton, D. A. Chromosome missegregation in human cells arises through specific types of kinetochore-microtubule attachment errors. Proc. Natl Acad. Sci. USA 108, 17974–17978 (2011).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kline-Smith, S. L. & Walczak, C. E. Mitotic spindle assembly and chromosome segregation: refocusing on microtubule dynamics. Mol. Cell 15, 317–327 (2004).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Prosser, S. L. & Pelletier, L. Mitotic spindle assembly in animal cells: a fine balancing act. Nat. Rev. Mol. Cell Biol. 18, 187–201 (2017).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zeng, X. et al. Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell 18, 382–395 (2010).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Warren, J. D., Orr, B. & Compton, D. A. A comparative analysis of methods to measure kinetochore-microtubule attachment stability. Methods Cell. Biol. 158, 91–116 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gregan, J., Polakova, S., Zhang, L., Tolic-Norrelykke, I. M. & Cimini, D. Merotelic kinetochore attachment: causes and effects. Trends Cell Biol 21, 374–381 (2011).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Etemad, B., Kuijt, T. E. & Kops, G. J. Kinetochore-microtubule attachment is sufficient to satisfy the human spindle assembly checkpoint. Nat. Commun. 6, 8987 (2015).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar
     

  • Tauchman, E. C., Boehm, F. J. & DeLuca, J. G. Stable kinetochore-microtubule attachment is sufficient to silence the spindle assembly checkpoint in human cells. Nat. Commun. 6, 10036 (2015).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar
     

  • Mitchison, T. & Kirschner, M. Microtubule assembly nucleated by isolated centrosomes. Nature 312, 232–237 (1984).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar
     

  • Fourest-Lieuvin, A. et al. Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-dependent kinase Cdk1. Mol. Biol. Cell 17, 1041–1050 (2006).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ubersax, J. A. et al. Targets of the cyclin-dependent kinase Cdk1. Nature 425, 859–864 (2003).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar
     

  • Yang, C. H., Lambie, E. J. & Snyder, M. NuMA: an unusually long coiled-coil related protein in the mammalian nucleus. J. Cell Biol. 116, 1303–1317 (1992).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Yang, C. H. & Snyder, M. The nuclear-mitotic apparatus protein is important in the establishment and maintenance of the bipolar mitotic spindle apparatus. Mol. Biol. Cell 3, 1259–1267 (1992).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kotak, S., Busso, C. & Gonczy, P. NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function. EMBO J. 32, 2517–2529 (2013).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kitagawa, M. et al. Cdk1 coordinates timely activation of MKlp2 kinesin with relocation of the chromosome passenger complex for cytokinesis. Cell Rep. 7, 166–179 (2014).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Schrock, M. S. et al. MKLP2 functions in early mitosis to ensure proper chromosome congression. J. Cell Sci. 135, jcs259560 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sun, M. et al. NuMA regulates mitotic spindle assembly, structural dynamics and function via phase separation. Nat. Commun. 12, 7157 (2021).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chen, Q., Zhang, X., Jiang, Q., Clarke, P. R. & Zhang, C. Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis. Cell Res. 18, 268–280 (2008).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Kabeche, L. & Compton, D. A. Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation. Nature 502, 110–113 (2013).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hegarat, N. et al. Cyclin A triggers mitosis either via the Greatwall kinase pathway or cyclin B. EMBO J. 39, e104419 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jumper, J. et al. Highly accurate protein structure prediction with AlphaFold. Nature 596, 583–589 (2021).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wood, D. J. & Endicott, J. A. Structural insights into the functional diversity of the CDK-cyclin family. Open Biol. 8, 180112 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Brown, N. R., Noble, M. E., Endicott, J. A. & Johnson, L. N. The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases. Nat. Cell Biol. 1, 438–443 (1999).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Tarricone, C. et al. Structure and regulation of the CDK5-p25nck5a complex. Mol. Cell 8, 657–669 (2001).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Poon, R. Y., Lew, J. & Hunter, T. Identification of functional domains in the neuronal Cdk5 activator protein. J. Biol. Chem. 272, 5703–5708 (1997).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Oppermann, F. S. et al. Large-scale proteomics analysis of the human kinome. Mol. Cell. Proteom. 8, 1751–1764 (2009).

    Article 
    CAS 

    Google Scholar
     

  • van den Heuvel, S. & Harlow, E. Distinct roles for cyclin-dependent kinases in cell cycle control. Science 262, 2050–2054 (1993).

    Article 
    ADS 
    PubMed 

    Google Scholar
     

  • Nakatani, Y. & Ogryzko, V. Immunoaffinity purification of mammalian protein complexes. Methods Enzymol. 370, 430–444 (2003).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Tyanova, S., Temu, T. & Cox, J. The MaxQuant computational platform for mass spectrometry-based shotgun proteomics. Nat. Protoc. 11, 2301–2319 (2016).

  • Tyanova, S. et al. The Perseus computational platform for comprehensive analysis of (prote)omics data. Nat. Methods 13, 731–740 (2016).

  • Ritchie, M. E. et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43, e47 (2015).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • R Core Team. R: a language and environment for statistical computing (2021).

  • Wickham, H. ggplot2: elegant graphics for data analysis (2016).

  • Slowikowski, K. ggrepel: automatically position non-overlapping text labels with “ggplot2” (2018).

  • Wu, T. et al. clusterProfiler 4.0: a universal enrichment tool for interpreting omics data. Innovation 2, 100141 (2021).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Deutsch, E. W. et al. The ProteomeXchange consortium in 2020: enabling ‘big data’ approaches in proteomics. Nucleic Acids Res. 48, D1145–D1152 (2020).

    CAS 
    PubMed 

    Google Scholar
     

  • Perez-Riverol, Y. et al. The PRIDE database and related tools and resources in 2019: improving support for quantification data. Nucleic Acids Res. 47, D442–D450 (2019).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Robinson, M. D., McCarthy, D. J. & Smyth, G. K. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics 26, 139–140 (2010).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Nagahara, H. et al. Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration. Nat. Med. 4, 1449–1452 (1998).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Mirdita, M. et al. ColabFold: making protein folding accessible to all. Nat. Methods 19, 679–682 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lu, C. et al. OPLS4: improving force field accuracy on challenging regimes of chemical space. J. Chem. Theory Comput. 17, 4291–4300 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Obenauer, J. C., Cantley, L. C. & Yaffe, M. B. Scansite 2.0: proteome-wide prediction of cell signaling interactions using short sequence motifs. Nucleic Acids Res. 31, 3635–3641 (2003).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

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